The Bio-Heat technology is an advancement and disruption in the industry to extend the resorption properties of PRF from 2-3 weeks to 4-6 months. This new development and protocol involves an additional heating process following centrifugation where the platelet poor plasma (PPP) layer is heated at specific temperatures to denature and reorganize albumin. This drastically extends the working resorption properties of PRF. The Bio-Heat technology has been extensively utilized in various fields of medicine and dentistry, including facial aesthetics.

By heating and denaturing albumin, a modification in the secondary structure after heating transforms liquid PRF into a tridimensional structure. The heating process consists of a pronounced modification in the surface structure of albumin within its resorption properties favoring more stability when implanted back into host tissues.